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Welcome
Our e-books "HISTAMINE CONFUSION" and "CANDIDA CONFUSION" are now available at www.confusionshop.com
HISTAMINE Research since 1980!
Histaminosis, Mastocytosis, Histamine Intolerance, Hypersensitivity
Disorder, Mastcell Activation Disorder
Welcome to the first comprehensive HISTAMINE Information site. This page was set-up with the help of health professionals and scientists who are involved in the study of Biogenic Amines/Histamines since over 30 years.
Histamine related health tests done by our laboratories:
PRIMARY-GROUP:
Histamine (plasma)
DAO/HNMT (with Heparin)
Total IgE
Hydrogen Breath Test, H2
B-Tryptase
a-Protryptase
Methylhistamine (Urine)
Chymase
Eosinophils
Basophils
Chromogranin A (in the absence of other factors...)
Vitamin/Mineral Screen
Cortisol
Virology
SYSTEM SPECIFIC TESTS (additional):
Urinary neurotransmitter test (Creatinine, DHEA, Dopamine, Epinephrine, GABA, glutamate)
WBC differential count (white blood cell morphology)
ANA (Anti-nuclear antibody)
Anti-dsDNA (double stranded DNA)
Prostaglandin D2
Leukotriene E4
Thromboxane A
Rheumatoid Factor
Virology (non-acute sample) – examples: Cytomegalovirus (CMV), Human Herpes Virus 7 (HHV-7), Coxsackie B, Echo virus-9, Parvo B-19, XMRV/PMLV
Dental bacteria DNA
Symptom specific hormone test e.g. TSH
C-reactive protein
Cholesterol
Blood sugar
IgA, IgD, IgM, IgG
Autonomic nervous system test through heart rate variability
Stool analysis/ pathogens
(read details about these tests on the TEST page)
Histamine Intolerance is not the same as Non-Allergic-Histaminosis, although both are very close related.
Histaminosis (enteral histaminosis and cellular histaminosis) is a more complex problem than just "Histamine Intolerance" (a reaction to foods rich in histamines). Because of its wide range of symptoms it is a) difficult to diagnose and b) not easy to treat.
Histamine problems are very much recognised by health authorities/healthcare practitioners in several countries in the world, but not yet in the UK.
Lots of "experts" are now setting up websites or writing books about histamine intolerance, without supplying proper information (or even having proper information). Very often these sites copy from each other and therefore lists regarding histamine-rich foods and foods to avoid are more and more the opposite of helpful.
New Histamine Intolerance and Histamine Awareness pages are being set up daily...
The result: patients get more and more confused because of self proclaimed experts who are trying to invent the wheel new!
In severe histaminosis, the food aspect might play a role not higher than 30% (although an improvement of 30% is already a good start).
There are now new histamine intolerance supplements on the market, which might ease some symptoms to only one part of a complex health problem - the reaction to histamine-rich foods, but very often do not work at all.
Our MSML laboratory studied the supplements (like DAOsin and Histame) and the medication, which works only or predominantly on Receptor 1 (like over-the-counter anti-histamines) and is in the final phase of a comparison study, which does not show many benefits for histamine/histaminosis sufferers.
These supplements/medication do not even consider the relation between the Histamine receptor H1 - H4.
Most patients believe, that they suffer from unidentified sensitivities/allergies. Our questions:
Do you have enough of long-term exclusion diets?
Do you have enough of being told "you have IBS or candida"?
Do you have enough of being told that you have parasites?
Do you trust high street allergy tests (Kinesiologogy, Vega, BiCom, York, etc.) less and less?
Have a look if your problem might be related to histaminosis or histamine intolerance.
And please... if you ever have been diagnosed with "Candida" or "you have a wheat and dairy intolerance"... just forget this nonsense and start thinking about a serious approach to your health issues.
One of the patients of our Immune Clinic London (go to www.immunecliniclondon.com )
Ella X. is finalizing her book "The Red Wine Headache Cook Book" with our 100% support. To visit Ella's website go to www.lowhistaminerecipes.com
(you can dowenload the "The Candida Confusion" and other publications from our other website. Please click here www.nutritionlondon.net/17/Research,-Articles,-Downloads.html
We are specialists in testing and treating:
SIBO (Small Intestinal Bacterial Overgrowth)
Histaminosis and related problems
Food Allergies and Intolerances
Histamine Intolerance
Tyramine Intolerance
Biogenic Amines
PFPS (Post Foodpoisoning Syndrome)
Chronic Fatigue
Dysbacteriosis
Viruses
Fungi
ON THIS PAGE
- INTRODUCTION
- "THE HISTAMINE CONNECTION"
- News: "HIGH STREET" ALLERGY TESTS - avoid them!
- PHARMACEUTICAL INHIBITORS OF DIAMINOXIDASE
- OUR NEW ADDRESSES
- Links
INTRODUCTION
Histamines are mainly connected with allergic responses, but also with digestive disorders, joint pain, inflammation, fatigue and depression/anxieties (see also: histaminergic neurones)
There is increasing evidence that Enteral Histaminosis or Histamine Intolerance (HIT) is a major cause of food hypersensitivity/food intolerance, rashes/flushing/other skin irritation and especially Irritable Bowel Syndrome (IBS)/IBS related symptoms.
Cellular Histaminosis is also a possible cause of adverse reactions and/or dysfunction of the immune system, but is not well researched. Patients very often feel:
severe fatigued
flu-like symptoms
fibromyalgia/unidentified joint and muscle pain
Histamine problems can lead to allergic reactions to food, environmental allergens even if the IgE response is mild or abscent!
Approximately 2 % of the population suffer from a severe form of histaminosis or reaction to other Biogenic Amines like tyramines, putrescines, etc). 10% or more have some reaction to Biogenic Amines.
These figures show that HIT and Biogenic Amine reaction is now a vastly more serious health problem than all food allergies put together!
Digestive problems (prolonged diarrhoea or constipation), bloating, stomach pain, heartburn, belching, acid reflux but also tension/cluster headaches, migraines, palpitation, low blood pressure, urticaria, eczema, hay fever and asthma can be signs of a histamine intolerance (HIT) or a problem with other Biogenic Amines (BA) like Tyramines (very much connected with Migraines and Cluster Headaches).
Excess amount of histamines are controlled/eliminated by the enzymes DIAMINOXIDASE (DAO) and N-METHYLTRANSFERASE (HNMT). Many other enzymes like MAO-b seem to play important roles as well.
foto: Dermatology Online Journal
"THE HISTAMINE CONNECTION"
Just to mention some connections:
- Histamines are produced as a part of the inflammatory process during the development of arthritis. They make the blood vessels surrounding the joints especially vulnerable to leakage, and thereby render the joints more susceptible to inflammatory attacks.
- Research shows that this kind of histamine release takes place in other immune disorders like Lyme disease, lupus or even diabetes.
- It was also proven by S. Ida et al that viruses are capable to play a role in histamine release. Leucocytes infected by viruses can trigger a histamine release … even if the virus is inactive.
Human CD21 has previously been described as a receptor for the C3d,g and iC3b proteins of complement, as a receptor for the gp350/220 envelope glycoprotein of the Epstein-Barr virus (EBV) and also as a receptor for interferon-alpha (IFN-alpha). The CD21 is involved in histamine release.
- Altered thyroid function can lead to histamine release – or does histamine release trigger altered thyroid function? Some studies show, that chronic urticaria (CU) – an over-expression of histamines – is related to changes in thyroid function.
Scientific studies (a selection is available on our SCIENCE site) over the last decades have made connection between:
Histamines and ALLERGIES
Histamines and IRRITABLE BOWEL SYNDROME
Histamines and CROHN'S DISEASE
Histamines and ULCERATIVE COLITIS
Histamines and CHRONIC FATIGUE
Histamines and FIBROMYALGIA
Histamines and INCREASED GUT PERMEABILITY
Histamines and RHEUMATOID ARTHRITIS
Histamines and MIGRAINES and CLUSTER HEADACHES
Histamines and SKIN DISEASES
Histamines and DEPRESSION
Histamines and SCHIZOPHRENIA
Histamines and ECTOPIC HEART BEAT
IN THE NEWS: "High Street food allergy tests mislead consumers"
SUNDAY TIMES 23/02/2010 LINK:
http://www.timesonline.co.uk/tol/life_and_style/health/article7034867.ece
COMMENT:
Yes, many of these tests are not accepted and questionable!
We see the "victims" of these tests every day!
Every serious medical practitioner and medical scientists knows that only an IgE test can determine a 'classical' allergy.
And York? IgG? Even accepted by Allergy UK? We remember the case where a friend did send three samples to York laboratories... under three different names...
now guess... RIGHT! Three completely different result.
Please... If a VEGA or BICOM or whatever machine can really tests for certain yeasts and bacteria in the intestines… or hundreds of food-sensitivities, it would be a world sensation... This machine would probably cost a couple of million pounds... and not just 400 or so...
PHARMACEUTICAL INHIBITORS OF DIAMINOXIDASE
Studies have shown that histamine-intolerant individuals may have a deficiency of the enzyme, diamineoxidase (extracellular) and/or N-methyltransferase (intracellular), in the small intestinal mucosa, resulting in decreased breakdown, and increased absorption of histamine in the gastrointestinal tract.
Diamineoxidase levels are known to be about 500-fold elevated in pregnancy (safety net to protect the unborn. This shows the incredible importance of the DAO).
Almost 100 drugs have been shown to inhibit diamineoxidase, including:
- Clauvulanic acid found in Augmentin (antibiotics)
- Doxycyline
- Isoniazid (antibiotics used to treat tuberculosis)
- Metoclopropramide (used to treat 'stomach upsets')
- Verapamil (used to treat heart conditions)
- Promethazine
- Monoamine oxidase inhibitors, MAOI (older drugs used to treat depression)
Zinc, Manganese, Niacin, Vitamin B12 and folic acid may also increase histamine levels.
ADDRESSES:
We have new consultation rooms at the Integrated Medical Centre, 121 Crawford Street, W1U 6BE (near Baker Street) , 020 7224 5111. Our laboratory was set up temporarily in South London and is now located in Belgium where it serves our practitioners from the UK, Germany, Holland, Belgium and France.
LINKS TO our Clinics and other websites
www.immunecliniclondon.com
www.immuneclinicresearch.com
www.chronicfatiguelondon.com
www.ibsforum.co.uk
www.msml-laboratories.com
www.bacteriaclinic.com
www.parasiteclinic.com
www.stop-readymeals.com
www.nutritionlondon.net
www.lasercliniclondon.com
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