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Welcome
Welcome to the first comprehensive HISTAMINE Information site. This page was set-up with the help of health professionals and scientists who are involved in the study of Biogenic Amines/Histamines since over 20 years.
Histaminosis (enteral histaminosis and cellular histaminosis) is a more complex problem than just "Histamine Intolerance" (a reaction to foods rich in histamines). Because of its wide range of symptoms it is a) difficult to diagnose and b) not easy to treat.
Histamine problems are very much recognised by health authorities/healthcare practitioners in several countries in the world, but not yet in the USA and UK.
Lots of "experts" are now setting up websites or writing books about histamine intolerance, without supplying proper information. Very often these sites copy from each other and therefore lists regarding histamine-rich foods and foods to avoid are more and more the opposite of helpful.
In severe histaminosis, the food aspect might play a role not higher than 30% (although an improvement of 30% is already a good start).
There are now new histamine intolerance supplements on the market, which might ease some symptoms to only one part of a complex health problem - the reaction to histamine-rich foods, but very often do not work at all.
Our MSML laboratory studied the supplements (like DAOsin and Histame) and the medication, which works only or predominantly on Receptor 1 (like over-the-counter anti-histamines) and is in the final phase of a comparison study, which does not show many benefits for histamine/histaminosis sufferers.
These supplements/medication do not even consider the relation between the Histamine receptor H1 - H4.
Most patients believe, that they suffer from unidentified sensitivities/allergies. Our questions:
Do you have enough of long-term exclusion diets?
Do you have enough of being told "you have IBS or candida"?
Do you have enough of being told that you have parasites?
Do you trust high street allergy tests (Kinesiologogy, Vega, BiCom, York, etc.) less and less?
Have a look if your problem might be related to histaminosis or histamine intolerance.
And please... if you ever have been diagnosed with "Candida" or "you have a wheat and dairy intolerance"... just forget this nonsense and start thinking about a serious approach to your health issues.
One of the patients of our Immune Clinic London (go to www.immunecliniclondon.com )
Ella X. is finalizing her book "The Red Wine Headache Cook Book" with our 100% support. To visit Ella's website go to www.lowhistaminerecipes.com
(you can dowenload the "The Candida Confusion" and other publications from our other website. Please click here www.nutritionlondon.net/17/Research,-Articles,-Downloads.html
We are specialists in testing and treating:
SIBO (Small Intestinal Bacterial Overgrowth)
Histaminosis and related problems
Food Allergies and Intolerances
Histamine Intolerance
Tyramine Intolerance
Biogenic Amines
PFPS (Post Foodpoisoning Syndrome)
Chronic Fatigue
Dysbacteriosis
Viruses
Fungi
ON THIS PAGE
- INTRODUCTION
- "THE HISTAMINE CONNECTION"
- News: "HIGH STREET" ALLERGY TESTS - avoid them!
- PHARMACEUTICAL INHIBITORS OF DIAMINOXIDASE
- OUR NEW ADDRESSES
- Links
INTRODUCTION
Histamines are mainly connected with allergic responses.
There is increasing evidence that Enteral Histaminosis or Histamine Intolerance (HIT) is a major cause of food hypersensitivity/food intolerance, rashes/flushing/other skin irritation and especially Irritable Bowel Syndrome (IBS)/IBS related symptoms.
Cellular Histaminosis is also a possible cause of adverse reactions and/or dysfunction of the immune system, but is not well researched. Patients very often feel:
severe fatigued
flu-like symptoms
fibromyalgia
unidentified joint and muscle pain
Approximately 2 % of the population suffer from a severe form of histaminosis or reaction to other Biogenic Amines. 10% or more have some reaction to Biogenic Amines.
These figures show that HIT and Biogenic Amine reaction is now a vastly more serious health problem than all food allergies put together!
Digestive problems (prolonged diarrhoea or constipation), bloating, stomach pain, heartburn, belching, acid reflux but also tension/cluster headaches, migraines, palpitation, low blood pressure, urticaria, eczema, hay fever and asthma can be signs of a histamine intolerance (HIT) or a problem with other Biogenic Amines (BA) like Tyramines (very much connected with Migraines and Cluster Headaches).
Excess amount of histamines are controlled/eliminated by the enzymes DIAMINOXIDASE (DAO) and N-METHYLTRANSFERASE (HNMT). Many other enzymes like MAO-b seem to play important roles as well.
foto: Dermatology Online Journal
"THE HISTAMINE CONNECTION"
Just to mention some connections:
- Histamines are produced as a part of the inflammatory process during the development of arthritis. They make the blood vessels surrounding the joints especially vulnerable to leakage, and thereby render the joints more susceptible to inflammatory attacks.
- Research shows that this kind of histamine release takes place in other immune disorders like Lyme disease, lupus or even diabetes.
- It was also proven by S. Ida et al that viruses are capable to play a role in histamine release. Leucocytes infected by viruses can trigger a histamine release … even if the virus is inactive.
Human CD21 has previously been described as a receptor for the C3d,g and iC3b proteins of complement, as a receptor for the gp350/220 envelope glycoprotein of the Epstein-Barr virus (EBV) and also as a receptor for interferon-alpha (IFN-alpha). The CD21 is involved in histamine release.
- Altered thyroid function can lead to histamine release – or does histamine release trigger altered thyroid function? Some studies show, that chronic urticaria (CU) – an over-expression of histamines – is related to changes in thyroid function.
Scientific studies (a selection is available on our SCIENCE site) over the last decades have made connection between:
Histamines and ALLERGIES
Histamines and IRRITABLE BOWEL SYNDROME
Histamines and CROHN'S DISEASE
Histamines and ULCERATIVE COLITIS
Histamines and CHRONIC FATIGUE
Histamines and FIBROMYALGIA
Histamines and INCREASED GUT PERMEABILITY
Histamines and RHEUMATOID ARTHRITIS
Histamines and MIGRAINES and CLUSTER HEADACHES
Histamines and SKIN DISEASES
Histamines and DEPRESSION
Histamines and SCHIZOPHRENIA
Histamines and ECTOPIC HEART BEAT
IN THE NEWS: "High Street food allergy tests mislead consumers"
SUNDAY TIMES 23/02/2010 LINK:
http://www.timesonline.co.uk/tol/life_and_style/health/article7034867.ece
COMMENT:
Yes, all these tests are misleading and rubbish! And I believe it is no surprise that Holland & Barrett offers these "joke-sessions", which they call "tests"
I see the victims of these absurd and crazy tests every day!
It is about time to stop this nonsense once and for all. For these "practitioners" every patient has problems with wheat and dairy (The bad guys of the century :-)... and of course yeast.
Every serious medical practitioner and medical scientists knows that only an IgE test can determine a 'classical' allergy.
Quacks und weekend practitioners are making a lot of money with the fears and food obsession of patients.
And York? IgG? Even accepted by Allergy UK? (There have been more serious in the past anyway)... I remember the case where a friend did send three samples to York laboratories... under three different names...
now guess... RIGHT! Three completely different resultPlease, dear patient: Think! If a VEGA or BICOM or whatever machine can really tests for certain yeasts and bacteria in the intestines… or hundreds of food-sensitivities, it would be a world sensation... This machine would probably cost a couple of million pounds... and not just 400 or so...
I had my independent lab and clinic under the roof of the Hale Clinic…and what I saw and experienced there is unbelievable! Amazing, how many people are willing to believe even the most utterly nonsense… Sending electric currents via copper plates through your body... Please... I can see the (none-existent) yeasts and bacteria laughing themselves to death.
Peter Smith of the Hale Clinic and his Pseudo Allergies :-) There is a medical definition for Pseudo-Allergies, like Histaminosis or Tyraminosis... these are complicated diseases and definitely not "weekly changing allergies"...
PHARMACEUTICAL INHIBITORS OF DIAMINOXIDASE
Studies have shown that histamine-intolerant individuals may have a deficiency of the enzyme, diamineoxidase (extracellular) and/or N-methyltransferase (intracellular), in the small intestinal mucosa, resulting in decreased breakdown, and increased absorption of histamine in the gastrointestinal tract.
Diamineoxidase levels are known to be about 500-fold elevated in pregnancy (safety net to protect the unborn. This shows the incredible importance of the DAO).
Almost 100 drugs have been shown to inhibit diamineoxidase, including:
- Clauvulanic acid found in Augmentin (antibiotics)
- Doxycyline
- Isoniazid (antibiotics used to treat tuberculosis)
- Metoclopropramide (used to treat 'stomach upsets')
- Verapamil (used to treat heart conditions)
- Promethazine
- Monoamine oxidase inhibitors, MAOI (older drugs used to treat depression)
Zinc, Manganese, Niacin, Vitamin B12 and folic acid may also increase histamine levels.
ADDRESSES:
We have a new consultation room at the Integrated Medical Centre, 121 Crawford Street, W1U 6BE (near Baker Street) , 020 7224 5111. Our laboratory is set up temporarily in South London.
We are setting up new clinics with laser treatment rooms, additional therapyrooms, laser distribution centre, special laboratories, research units and health product distribution centre in
PRIMROSE HILL
We will move with Dirk Budka Ltd, AIM Collaborations Ltd, MSML-Laboratory into our new premises in Primrose Hill in Seoptember 2010.
LINKS TO our Clinics and other websites
www.immunecliniclondon.com
www.immuneclinicresearch.com
www.chronicfatiguelondon.com
www.ibsforum.co.uk
www.msml-laboratories.com
www.bacteriaclinic.com
www.parasiteclinic.com
www.stop-readymeals.com
www.nutritionlondon.net
www.lasercliniclondon.com
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