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Welcome
Welcome to the first HISTAMINE Information site. Learn all about histamines and health problems caused by imbalances of histamines and other biogenic amines
ON THIS PAGE
- INTRODUCTION
- "THE HISTAMINE CONNECTION"
- PHARMACEUTICAL INHIBITORS OF DIAMINOXIDASE
- OUR NEW ADDRESSES
INTRODUCTION
Histamines are mainly connected with allergic responses.
There is increasing evidence that Enteral Histaminosis or Histamine Intolerance (HIT) is a major cause of food hypersensitivity/food intolerance, rashes/flushing/other skin irritation and especially Irritable Bowel Syndrome (IBS)/IBS related symptoms.
Cellular Histaminosis is also a possible cause of adverse reactions and/or dysfunction of the immune system, but is not well researched.
Approximately 2 % of the population suffer from a severe form of histaminosis or reaction to other Biogenic Amines. 10% or more have some reaction to Biogenic Amines.
This figures show that HIT and Biogenic Amine reaction is now a vastly more serious health problem than all food allergies put together!
Digestive problems (prolonged diarrhoea or constipation), bloating, stomach pain, heartburn, belching, acid reflux but also tension/cluster headaches, migraines, palpitation, low blood pressure, urticaria, eczema, hay fever and asthma can be signs of a histamine intolerance (HIT) or a problem with other Biogenic Amines (BA) like Tyramines (very much connected with Migraines and Cluster Headaches).
Excess amount of histamines are controlled/eliminated by the enzymes DIAMINOXIDASE (DAO) and N-METHYLTRANSFERASE (HNMT). Many other enzymes like MAO-b seem to play important roles as well.
foto: Dermatology Online Journal
"THE HISTAMINE CONNECTION"
Just to mention some connections:
- Histamines are produced as a part of the inflammatory process during the development of arthritis. They make the blood vessels surrounding the joints especially vulnerable to leakage, and thereby render the joints more susceptible to inflammatory attacks.
- Research shows that this kind of histamine release takes place in other immune disorders like Lyme disease, lupus or even diabetes.
- It was also proven by S. Ida et al that viruses are capable to play a role in histamine release. Leucocytes infected by viruses can trigger a histamine release … even if the virus is inactive.
Human CD21 has previously been described as a receptor for the C3d,g and iC3b proteins of complement, as a receptor for the gp350/220 envelope glycoprotein of the Epstein-Barr virus (EBV) and also as a receptor for interferon-alpha (IFN-alpha). The CD21 is involved in histamine release.
- Altered thyroid function can lead to histamine release – or does histamine release trigger altered thyroid function? Some studies show, that chronic urticaria (CU) – an over-expression of histamines – is related to changes in thyroid function.
Scientific studies (a selection is available on our SCIENCE site) over the last decades have made connection between:
Histamines and ALLERGIES
Histamines and IRRITABLE BOWEL SYNDROME
Histamines and CROHN'S DISEASE
Histamines and ULCERATIVE COLITIS
Histamines and CHRONIC FATIGUE
Histamines and FIBROMYALGIA
Histamines and LEAKY GUT
Histamines and RHEUMATOID ARTHRITIS
Histamines and MIGRAINES and CLUSTER HEADACHES
Histamines and SKIN DISEASES
Histamines and DEPRESSION
Histamines and SCHIZOPHRENIA
PHARMACEUTICAL INHIBITORS OF DIAMINOXIDASE
Studies have shown that histamine-intolerant individuals may have a deficiency of the enzyme, diamineoxidase (extracellular) and/or N-methyltransferase (intracellular), in the small intestinal mucosa, resulting in decreased breakdown, and increased absorption of histamine in the gastrointestinal tract.
Diamineoxidase levels are known to be about 500-fold elevated in pregnancy (safety net to protect the unborn. This shows the incredible importance of the DAO).
Almost 100 drugs have been shown to inhibit diamineoxidase, including:
- Clauvulanic acid found in Augmentin (antibiotics)
- Doxycyline
- Isoniazid (antibiotics used to treat tuberculosis)
- Metoclopropramide (used to treat 'stomach upsets')
- Verapamil (used to treat heart conditions)
- Promethazine
- Monoamine oxidase inhibitors, MAOI (older drugs used to treat depression)
Zinc, Manganese, Niacin, Vitamin B12 and folic acid may also increase histamine levels.
ADDRESSES:
We have a new consultation room at the Integrated Medical Centre, 121 Crawford Street, W1U 6BE (near Baker Street) , 020 7224 5111. Our laboratory is set up temporarily in South London.
We are setting up new clinics with laser treatment rooms, additional therapyrooms, laser distribution centre, special laboratories, research units and health product distribution centre at two locations:
A) ANGEL
B) PRIMROSE HILL
We will move with Dirk Budka Ltd, AIM Collaborations Ltd, MSML-Laboratories into our new premises by end of March 2010.
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